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KMID : 0370219860300030157
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Yakhak Hoeji
1986 Volume.30 No. 3 p.157 ~ p.162
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Postsynaptic alpha1- and alpha2-Adrenoceptors in Rat Isolated Aorta
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임광진/Im GJ
조윤성/고광호/김미영/Cho YS/Ko KH/Kim MY
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Abstract
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alpha-Adrenoceptor subtypes in the isolated rat aortic strips were examined by using agonists and antagonists which have varying selectivity for alpha1- and alpha2-adrenoceptors. Norepinephrine and phenylephrine produced a similar magnitude of maximum contractions. pA2 values for prazosin and yohimbine were not significantly different using norepinephrine or phenylephrine as the agonist, suggesting a single population of alpha-adrenoceptor. Contractile responses produced by alpha-agonists were antagonized more effectively by prazosin (approximately 1000 fold) than by yohimbine.
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